Main Interests:

Metabolism is undoubtedly one of the currently rediscovered fields of research and it will certainly be a niche of scientific discoveries that will allow the evolution of the knowledge and treatment of diseases, namely cancer. The metabolic adaptation of cancer cells not only permits the development and establishment of a tumor, in a certain microenvironment, but it also conditions the response to the therapy.
Metabolic adaptation cannot be assessed exclusively from the cancer cell point of view but should as well consider the contribution of stromal (non-cancerous) cells in the same tissue or organ. Metabolism does not consist solely of the intracellular network that shares and provides organic compounds among the various chemical reactions that make up the metabolic dynamics, but also encompasses the extracellular organic and signaling molecules that supplement and mediate stimuli, which regulate the entire metabolic functioning of a cell. In cancer, the surrounding cells (fibroblasts, endothelial cells, immune cells and adipocytes) influence the tumor microenvironment, the tumor cell biology and metabolism.
The main research area of CMM group is cancer metabolism not only the metabolic adaptive features that allow the establishment of a tumor in a certain microenvironment but also the way these metabolic adaptations limit the response to therapy.

Our projects assess the role of cancer metabolism in different in vitro and in vivo cancer models as leukemia, lung, breast, colon, uterine cervix and ovarian cancer.
Our studies have already consolidated the role of transporters as mediators of the uptake of cytotoxic compounds, as monocarboxylate transporter 1 (MCT1) in uterine cervix cancer (Silva et al., 2016) and in acute myeloid leukemia (Lopes-Coelho et al., 2017). New therapeutic targets in the lipid metabolic course have also been pointed out by us in breast cancer, such as fatty acids transporter protein 1, FATP1 (Lopes-Coelho et al, 2018). The genetic background underlying mechanisms of resistance in cancer is a crucial issue in our research and we have disclosed hepatocyte nuclear factor  (HNF1 as the main responsible for the thiold (cysteine and glutathione) dynamic pattern responsible for the resistance to oxidative/alkylant therapy used in cancer treatment (Lopes-Coelho et al., 2016; Nunes et al, 2018).
Currently, we are developing strategies to abrogate the function of FATP1 to destabilize cancer microenvironment metabolic cross-talks, and the cysteine uptake by inhibiting transporters EAAT3 and xCT to overcome cancer resistance.

A more recent and promising project concerning the role of monocytes in cancer neangiogenesis is being developed, assessing the metabolic dynamic along monocytes differentiation.

Projects as PI:

2017-2019-Targeting monocytes as angiogenesis promoters in cancer- New application for old drugs; Funded by iNOVA4Health, FCT

2015-2017- Ovarian cancer (OC) a suitable model to define metabolic profile as a tool to predict chemoresistance; Funded by iNOVA4Health, FCT

2011-2013- "Monocarboxylate transporters (MCTs) as putative therapeutic targets in acute myeloid leukaemia (AML)"- Terry Fox; Liga Portuguesa Contra o Cancro, Núcleo Regional Sul (PI: Jacinta Serpa, CEDOC-FCM-UNL; CIPM-IPOLFG)

2011-2013- "Role of Lactate Rich Microenvironment in Uterine Cervix Cancer Progression"- Fundação Luso-Americana para o Desenvolvimento (FLAD) (PI: Jacinta Serpa, CEDOC-FCM-UNL)

Member of the following projects:

2016-2018- (per)Sulfidomics: benchmarking mechanisms underlying drug toxicity and drug resistance in precision medicine; Funded by iNOVA4Health, FCT

2015-2017-Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression; Funded by iNOVA4Health, FCT

2014-2016- Projecto supported by LRI Innovative Science Award 2014; PI: Doutora Alexandra Antunes

2014/2016- “Biomarcadores e potenciais alvos terapêuticos em carcinoma do colo uterino”; Terry Fox- Liga Portuguesa Contra o Cancro e Embaixada do Canadá; PI: Ana Félix.

2013/2016- “Risco de Cancro Familiar e Individual – Identificação de Novos Genes” ; Projeto TVI

May 2013- PTDC/BIM-ONC/1242/2012: "Metaboloma do líquido cefalorraquidiano em doentes oncológicos”- PI: Tânia Carvalho- IMM

Selected Publications:

Book chapters:

• Serpa J. Metabolic remodeling as a way of adapting to tumor microenvi-ronment (TME), a job of several holders; Book title: Tumor Microenvironment - The main driver of metabolic adaptation; from Advances in Experimental Medicine and Biology series; Springer Nature, 2020, DOI: 10.1007/978-3-030-34025-4_1

• Nunes SC, Serpa J. Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis; Book title: Tumor Microenvironment - The main driver of metabolic adaptation; from Advances in Experimental Medicine and Biology series; Springer Nature, 2020, DOI: 10.1007/978-3-030-34025-4_4

• Hipólito A, Mendes C, Serpa J. The metabolic remodelling in lung cancer and its putative conse-quence in therapy response; Book title: Tumor Microenvironment - The main driver of metabolic adaptation; from Advances in Experimental Medicine and Biology series; Springer Nature, 2020, DOI: 10.1007/978-3-030-34025-4_16

• Lopes-Coelho F, Martins F, Serpa J. Endothelial cells (ECs) metabolism: a valuable piece to disentangle cancer biology; Book title: Tumor Microenvironment - The main driver of metabolic adaptation; from Advances in Experimental Medicine and Biology series; Springer Nature, 2020, DOI: 10.1007/978-3-030-34025-4_8

• Domingues, G; Gouveia-Fernandes, S.; Serpa, J. Dynamics of VEGF-A and its Receptors in Cancer Vascularization – an Overview; Capítulo do livro: Recent Cancer Research and Treatment; IConcept Press - ISBN 978-1-922227-386

• J. Serpa. Uterine Cervix Cancer Cells Re-Establish the Natural Lactate Rich Microenvironment, favoring Disease Progression; Capitulo de Livro; Open access e-Books, Research & Reviews on Cervical Cancer; ISBN 978-81-935757-4-1

Papers:
 

• Nunes SC, Ramos C, Santos I, Mendes C, Silva F, Vicente JB, Pereira SA, Félix A, Gonçalves LG, Serpa J. Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming. Frontiers in Cell and Developmental Biology. 2021 (9) 2107. doi: 10.3389/fcell.2021.72241.

• Lopes-Coelho F, Silva F, Hipólito A, Mendes C, Sequeira CO, Pires RF, Almeida AM, Bonifácio VDB, Pereira SA, Serpa J. The activation of endothelial cells relies on a ferroptosis-like mechanism: novel perspectives in management of angiogenesis and cancer therapy. Front. Oncol., 10 May 2021. doi:10.3389/fonc.2021.656229.

• André S, Pinto AE, Silva GL, Silva F, Serpa J, Félix A. Male Breast Cancer-Immunohistochemical Patterns and Clinical Relevance of FASN, ATF3, and Collagen IV. Breast Cancer (Auckl). 2021 Apr 8;15:11782234211002496. doi: 10.1177/11782234211002496.

• Lopes-Coelho F, Martins F, Pereira SA, Serpa J. Anti-Angiogenic Therapy: Current Challenges and Future Perspectives. Int. J. Mol. Sci. 2021, 22(7), 3765; https://doi.org/10.3390/ijms22073765

• Bonifácio VDB, Pereira SA, Serpa J, Vicente JB. Cysteine metabolic circuitries: druggable targets in cancer. Br J Cancer. 2021 Mar;124(5):862-879. doi: 10.1038/s41416-020-01156-1.

• Serpa J. Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival. Front Oncol. 2020 Jun 23;10:947. doi: 10.3389/fonc.2020.00947.

• Martins F, Gonçalves LG, Pojo M, Serpa J. Take Advantage of Glutamine Anaplerosis, the Kernel of the Metabolic Rewiring in Malignant Gliomas. Biomolecules. 2020 Sep 26;10(10):1370. doi: 10.3390/biom10101370.

• Hipólito A, Nunes SC, Vicente JB, Serpa J. Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer. Molecules. 2020 Sep 1;25(17):3984. doi: 10.3390/molecules25173984.

• Mendes C, Serpa J. Revisiting lactate dynamics in cancer-a metabolic expertise or an alternative attempt to survive? J Mol Med (Berl). 2020 Oct;98(10):1397-1414. doi: 10.1007/s00109-020-01965-0.

• Bonifácio VDB, Pereira SA, Serpa J, Vicente JB. Cysteine metabolic circuitries: druggable targets in cancer. British Journal of Cancer. 2020 Nov 23: Pages 1—18.

• Lopes-Coelho F, Silva F, Gouveia-Fernandes S, Martins C, Lopes N, Domingues G, Brito C, Almeida AM, Pereira SA, Serpa J. Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis. Cells. 2020 Jan 1;9(1):107. doi: 10.3390/cells9010107.

• Cruz A, Mota P, Ramos C, Pires RF, Mendes C, Silva JP, Nunes SC, Bonifácio VDB, Serpa J. Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance. Antioxidants (Basel). 2020 Feb 3;9(2):133. doi: 10.3390/antiox9020133.

• Hipólito A, Nunes SC, Vicente JB, Serpa J. Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer. Molecules. 2020 Sep 1;25(17):E3984. doi: 10.3390/molecules25173984.

• Serpa J. Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival. Front Oncol. 2020 Jun 23;10:947. doi: 10.3389/fonc.2020.00947. eCollection 2020.

• Lopes-Coelho F, Martins F, Serpa J. Endothelial Cells (ECs) Metabolism: A Valuable Piece to Disentangle Cancer Biology. Adv Exp Med Biol. 2020;1219:143-159. doi: 10.1007/978-3-030-34025-4_8.

• Nunes SC, Serpa J. Recycling the Interspecific Relations with Epithelial Cells: Bacteria and Cancer Metabolic Symbiosis. Adv Exp Med Biol. 2020;1219:77-91. doi: 10.1007/978-3-030-34025-4_4.

• Mendes C, Serpa J. Revisiting lactate dynamics in cancer-a metabolic expertise or an alternative attempt to survive? J Mol Med (Berl). 2020 Aug 22. doi: 10.1007/s00109-020-01965-0. Online ahead of print.

• Serpa J. Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders. Adv Exp Med Biol. 2020;1219:1-34. doi: 10.1007/978-3-030-34025-4_1.

• Hipólito A, Mendes C, Serpa J. The Metabolic Remodelling in Lung Cancer and Its Putative Consequence in Therapy Response. Adv Exp Med Biol. 2020;1219:311-333. doi: 10.1007/978-3-030-34025-4_16.

• Lopes-Coelho F, Silva F, Gouveia-Fernandes S, Martins C, Lopes N, Domingues G, Brito C, Almeida AM, Pereira SA, Serpa J. Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis. Cells 2020, 9(1), 107; doi: 10.3390/cells9010107

• Mendes C, Serpa J. Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung Cancer. Antioxidants (Basel). 2019 Nov 29;8(12):603. doi: 10.3390/antiox8120603.

• Alves J, Brito G, Silveira M, Serpa J, Félix A, Simões P. Detection of human ovarian carcinoma from blood samples using scent dogs. Acta Obstet Ginecol Port 2019;13(3):155-159

• Santos I, Ramos C, Mendes C, Sequeira CO, Tomé CS, Fernandes DGH, Mota P, Pires RF, Urso D, Hipólito A, Antunes AMM, Vicente JB, Pereira SA, Bonifácio VDB, Nunes SC, Serpa J. Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation. Nutrients 2019 Oct; 11(10): 2523. Published online 2019 Oct 19. doi: 10.3390/nu11102523

• Mendes C, Serpa J. Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung Cancer. Antioxidants Antioxidants 2019, 8(12), 603; doi: 10.3390/antiox8120603

• Mendes C, Lopes-Coelho F, Ramos C, Martins F, Santos I, Rodrigues A, Silva F, André S, Serpa J. Unraveling FATP1, regulated by ER-b as a targeted breast cancer innovative therapy, Scientific reports 2019, Oct 1;9(1):14107. doi: 10.1038/s41598-019-50531-3.

• Casalou C, Faustino A, Silva F, Ferreira IC, Vaqueirinho D, Ferreira A, Castanheira P, Barona T, Ramalho JS, Serpa J*, Félix A*, Barral DC. Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling, Cancers 2019, Sep 29;11(10). pii: E1461. doi: 10.3390/cancers11101461. *Equal contribution

• Mota P, Pires RF, Serpa J, Bonifácio VDB. L-Buthionine Sulfoximine Detection and Quantification in Polyurea Dendrimer Nanoformulations. Molecules. 2019, Aug 27;24(17). pii: E3111. doi: 10.3390/molecules24173111

• Nunes J, Charneira C, Nunes C, Gouveia-Fernandes S, Serpa J, Morello J, Antunes AMM. A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications. Frontiers in Chemistry. 2019 Jul 31;7:532. doi: 10.3389/fchem.2019.00532.

• Lopes-Coelho F, Silva F, Hipólito A, Cardoso BA, Serpa J. Acetylation drives hepatocyte nuclear factor 1 stability by blocking proteasome-mediated degradation. Journal of Cellular Biochemistry. 2019 Jun;120(6):9337-9344 doi: 10.1002/jcb.28209

• Nunes SC, Lopes-Coelho F, Gouveia-Fernandes S, Ramos C, Pereira SA, Serpa J. Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer. BMC Evolutionary Biology 2018 Jun 19;18(1):97. doi: 10.1186/s12862-018-1214-1

• Nunes SC, Ramos C, Lopes-Coelho F, Sequeira CO, Silva F, Gouveia-Fernandes S, Rodrigues A, Guimarães A, Silveira M, Abreu S, Santo VE, Brito C, Félix A, Pereira SA, Serpa J. Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity. Scientific Reports. 2018 Jun 22;8(1):9513. doi: 10.1038/s41598-018-27753-y

• Nunes SC, Serpa J. Glutathione in Ovarian Cancer: A Double-Edged Sword. International Journal of Molecular Science 2018 Jun 26;19(7). pii:E1882. doi: 10.3390/ijms19071882

• Lopes-Coelho F, Gouveia-Fernandes S, Serpa J. (2018) Cooperation of cancer and normal cells is pivotal in cancer metabolic fitness. Tumour Biol. 2018 Feb;40(2):1010428318756203. doi: 10.1177/1010428318756203.

• Lopes-Coelho F, Gouveia-Fernandes S, Nunes SC, Serpa J. (2018) Metabolic Dynamics in Breast Cancer: Cooperation between Cancer and Stromal Cells. Journal of Clinical Breast Cancer Research, accepted

• Alteriis D, Cartenì F , Parascandola P, Serpa J , Mazzoleni S. (2018) Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death. Cell Cycle accepted

• Graça G. Desterro J, Sousa J, Fonseca C, Silveira M, Serpa J, Carvalho T, da Silva MG, Gonçalves LG. Identification of putative biomarkers for leptomeningeal invasion in B-cell non-Hodgkin lymphoma by NMR metabolomics. Metabolomics (2017) 13: 136.

• Grilo NM, João Correia M, Miranda JP, Cipriano M, Serpa J, Matilde Marques M, Monteiro EC, Antunes AMM, Diogo LN, Pereira SA. Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms. Eur J Pharm Sci. 2017 May 6;105:47-54. doi: 10.1016/j.ejps.2017.05.010.

• Lopes-Coelho F, Nunes C, Gouveia-Fernandes S, Rosas R, Silva F, Gameiro p, Carvalho T, Silva MG, Cabeçadas J, Dias, S, Gonçalves LG, Serpa J. Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients and a vehicle to kill cancer cells. Oncotarget, 2017 Aug 16;8(47):82803-82823 doi: 10.18632/oncotarget.20294.

• Gouveia-Fernandes S, Carvalho T, Domingues G, Bordeira-Carriço R, Dias S, Serpa J. Colorectal Cancer Aggressiveness is Related to Fibronectin Over Expression, Driving the Activation of SDF-1:CXCR4 Axis. Int J Cancer Clin Res 2016, 3:072:3(8) ISSN: 2378-3419

• Lopes-Coelho F, André S, Félix A, Serpa J. Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids. Mol Cell Endocrinol. 2017 Jan 22. pii: S0303- 7207(17)30044-8. doi:10.1016/j.mce.2017.01.031. 3.

• Silva F, Félix A, Serpa J. Functional redundancy of the Notch pathway in ovarian cancer cell lines. Oncol Lett. 2016 Oct;12(4):2686-2691. DOI: 10.3892/ol.2016.4959

• Lopes-Coelho F, Gouveia-Fernandes S, Gonçalves LG, Nunes C, Faustino I, Silva F, Félix A, Pereira SA, Serpa J. HNF1ß drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC).Tumour Biol. 2016 Apr;37(4):4813-29. doi: 10.1007/s13277-015-4290-5.

• Silva LS, Goncalves LG, Silva F, Domingues G, Maximo V, Ferreira J, Lam EW, Dias S, Felix A, Serpa J. STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment.Tumour Biol. 2016 Apr;37(4):5385-95. doi: 10.1007/s13277-015-4385-z. Epub 2015 Nov 12. doi: 10.1007/s13277-015-4385-z.

• Serpa, J.; Dias, S. Metabolic cues from the microenvironment act as a major selective factor for cancer progression and metastases formation. Cell Cycle. 2011 Jan 15;10(2):180-1. Epub 2011 Jan 15 DOI: 10.4161/cc.10.2.14476

• Serpa, J.; Caiado, F.; Carvalho, T.; Torre, C.; Casalou, C.; Gonçalves, L.; Lamosa, P.; Rodrigues, M.; Zhu, Z.; Lam, E.W.-F.; Dias, S. Butyrate rich colonic microenvironment is a relevant selection factor for metabolically adapted tumour cells. J. Biol. Chem. 2010 Dec 10;285(50):39211-23. doi:10.1074/jbc.M110.156026.

• Cachaço, A.S.; Carvalho, T.; Santos, A.C.; Igreja, C.; Fragoso, R.; Osório, C.; Ferreia, M.; Serpa, J.; Correia, S.; Pinto-do-Ó, P.; Dias S. TNF- Regulates the effecs of irradiation in the mouse bome marrow microenvironment. PLoS One. 2010 Feb 1;5(2):e8980. doi: 10.1371/journal.pone.0008980.

• Gomes, A.; Carvalho, T.; Serpa, J., Torre, C.; Dias, S. Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF1:CXCR4 axis.Blood. 2010 May 13;115(19):3886-94. Epub 2009 Dec 15. doi: 10.1182/blood-2009-08-240580.

• Azevedo, M.; Eriksson, S.; Mendes, N.; Serpa, J.; Figueiredo, C.; Resende, L.P.; Ruvoën-Clouet, N.; Haas, R.M; Borén, T.; LePendu, J.; David, L. (2008) Expressing the BabA Adhesin is Influenced by the Secretor Phenotype. Journal of Pathology, 215: 308–16 DOI: 10.1002/path.2363

• Mesquita, P.; Almeida, R.; Lunet, N.; Reis, C. A.; Santos Silva, L.F.; Serpa, J.; van Seuningen, I.; Barros, B.; David, L. (2006) Metaplasia - A Transdifferentiation process that facilitates cancer development. The model of gastric intestinal metaplasia. Critical ReviewsTM in Oncogenesis 12(1-2):3-26

• Serpa, J.; Mesquita, P.; Mendes, N.; Oliveira, C.; Almeida, R.; Santos Silva, F.; Reis, C.; Le Pendu, J.; David, L. (2005) Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation. Cancer Letters 242(2):191-7 DOI: 10.1016/j.canlet.2005.11.009

• Serpa, J.; Mendes, N.; Reis, C. A.; Santos Silva, L. F.; Almeida, R.; LePendu, J. and David, L. (2204) Two new FUT2 missense polymorphisms, 739G>A and 839T>C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal. Biochemical Journal, Nov 1;383(Pt. 3):469-74. DOI: 10.1042/BJ20040803

• Serpa, J., Lunet, N., Mendes, N., Barros, H. and David, L.(2004) Letter to the Editor: Lewis and Secretor status and Helicobacter pylori eradication. Epidemiol. Infect. 2004 Oct;132(5):997-8

• Nogueira, A.M.; Marques, T.; Soares, P.C.; David, L.; Reis, C.A.; Serpa, J.; Queiroz, D.M.; Rocha, G.A. and Rocha, A.C. (2003) Lewis antigen expression in gastric mucosa of children: relationship with Helicobacter pylori infection. Journal of Pediatric Gastroenterology and Nutrition vol 38(1): 85-91.

• Mesquita, P.; Jonckheere, N.; Almeida, R.; Ducourouble, M.P.; Serpa, J.; Silva, E.; Pigny, P.; Santos-Silva, F.; Reis, C.; Silberg, D.; Van Seuningen, I. and David, L. (2003) Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. Journal of Biological Chemistry vol 278(51): 51549-56 DOI: 10.1074/jbc.M309019200

• Serpa, J. , Almeida, R., Oliveira, C., Santos Silva, F., Silva, E., Reis, C., Le Pendu, J., Oliveira, G., Cunha Ribeiro, L. M. and David, L. (2003) Lewis enzyme (alpha 1-3/4 fucosyltransferase) point mutations do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population. Journal of Human Genetics vol 48 pp 183-189. DOI: 10.1007/s10038-003-0007-5

• Silva, E.; Teixeira, A.; David, L.; Carneiro, F.; Reis, C.; Sobrinho-Simões, J.; Serpa, J.; Veerman, E.; Bolscher, J. e Sobrinho-Simões, M. (2002). Mucins as key molecules for the classification of intestinal metaplasia of the stomach. Virchows Archiv vol 440(3) pp 311-317 DOI: 10.1007/s004280100531

• Morais, V. A.; Serpa, J.; Palma, A. S.; Costa, T.; Maranga, L. e Costa, J. (2001). Expression and characterisation of recombinant human alpha3/4-Fucosyltransferase III from Sf9 and Tn cells using the baculovirus expression system. Biochemical Journal vol 353 pp 719-725

Collaborations

- Eric WF Lam - Imperial college London, Faculty of Medicine, Department of Surgery & Cancer, UK
- Stefaan van Gool- University of Leuven
- Shinozuka Tsuyoshi - Daiichi Sankyo Co., Ltd
- João Nuno Moreira - Centro de Neuro-ciências da Universidade de Coimbra
- Valdemar Máximo- IPATIMUP e Faculdade de Medicina da Universidade do Porto
- José Cabeçadas - Instituto Português de Oncologia de Lisboa, Francisco Gentil
- Maria Gomes da Silva - Instituto Português de Oncologia de Lisboa, Francisco Gentil
- Ana Félix- Instituto Português de Oncologia de Lisboa, Francisco Gentil
- António Almeida - Instituto Português de Oncologia de Lisboa, Francisco Gentil e Hospital da Luz
- Saudade André - Instituto Português de Oncologia de Lisboa, Francisco Gentil
- Margarida Silveira - Instituto Português de Oncologia de Lisboa, Francisco Gentil
- Duarte Salgado - Instituto Português de Oncologia de Lisboa, Francisco Gentil
- Vasco Bonifácio - Instituto Superior Técnico da Universidade de Lisboa
- Alexandra Antunes - Instituto Superior Técnico da Universidade de Lisboa
- João B Vicente - Instituto de Tecnologia Química e Biológica
- Luís G Gonçalves - Instituto de Tecnologia Química e Biológica
- Sofia A Pereira – CEDOC, NOVA Medical School
- Duarte Barral – CEDOC, NOVA Medical School
- Cristina Casalou – CEDOC, NOVA Medical School

Team photos

No open positions.