Organizing Committee:
Michael Glickman
Petek Ballar
Rune Matthiesen
Henrique Girao
Tilman Grune
Allan Weissman
Rosa Barrio
Betul Karademir
Manolis Papamichos-Chronakis
Manuel Rodriguez

Local organisers:
Sandra Tenreiro
Regina Menezes
Ana Sofia Carvalho
Paula Ludovico
Paulo Pereira
Colin Adrain

Sessions:

November 3rd , 2016

Keynotes of Day1 by Shigeo Murata, Tokyo University, Japan

Session I: Intracellular proteolytic systems I: Proteasome structure, assembly and function (WG2)
Chairs: Arkaitz Carracedo Perez (WG6), Pascale Bomont (WG2)

Arkaitz Carracedo, CIC bioGUNE & IKERBASQUE, Spain
Prasanna Venkatraman, ACTREC, India

Session II: Intracellular proteolytic systems II: Autophagy (WG2)
Chairs: Teresa Zoladek (WG2)

Anne Simonsen, University of Oslo, Norway (WG2)
Gabor Banhegyi, Semmelweis University , Hungary (WG4)
Session III: Protein modification in intracellular proteolysis (WG1)
Chairs: Marc Piechaczyk (WG6), Isabelle Jupin (WG1), Sebastian Leon (WG1)

Frauke Melchior, ZMBH, Germany (WG3)
Amir Orian, Rappaport Research Institute, Israel (WG5)
Alfred Vertegaal , LUMC, Netherlands (WG1)

November 4th, 2016

Keynotes of Day2 by Rosa Barrio, CIC bioGUNE, SPAIN (WG3)

Session IV: Protein quality control, misfolding and aggregation (WG4)
Chairs: Adrienne Gorman (WG4), Rasmus Hartmann-Petersen (WG4)

John Christianson, Ludwig Cancer Research, UK (WG4)

Session V: Mitochondria and proteostasis

Chair: Andreas Bachmair (WG1), Gemma Marfany (WG6)

Miratul Muqit, University of Dundee, UK

Session VI: Regulation of cell signaling I- Activation of signaling cascades (WG3)
Chairs: Dan Lindholm (WG3), Henrique Girao (WG3)
Michael Clague, University of Liverpool, UK (WG3)
Simona Polo, IFOM, Italy (WG3)
Fumiyo Ikeda, IMBA, Austria (WG2)

Session VII: Tool Development in Proteostasis (WG6)
Chairs: Rune Matthiesen (WG1), Boris Turk (WG6)

Huib Ovaa, NKI Amsterdam, Netherlands (WG2)
Michael Glickman, Technion Israel Institute of Technology, Israel (WG1)

November 5th, 2016

Keynotes of Day3 by Tilman Grune, German Institute of Human Nutrition, Germany

Session VIII: Regulation of cell proliferation and differentiation (WG5)
Chairs: Dimitris Xirodimas (WG5), Christine Blattner (WG5)
Dimitris Xirodimas
Session IX: Intracellular Proteostasis and Health I: Aging and Proteostasis WG6)
Chairs: Wiep Scheper (WG4), Efthimios Skoulakis (WG6)

Thorsten Hoppe, University of Cologne, Germany (WG4)
Carina Holmberg, University of Helsinki, Finland (WG2)

Session X: Intracellular Proteostasis and Health II: Oxidative Stress and Proteostasis (WG6)
Chairs: Gerasimos Sykiotis (WG6)

Bertrand Friguet, INSERM, France
Niki Chondrogianni, NHRF, Greece (WG2)

Session XI: Intracellular Proteostasis and Health III: Human Diseases and Proteostasis (WG6)
Chairs: Rosa Farras Rivera (WG6)
Konstanze F. Winklhofer, Ruhr University Bochum, Germany
Eric Reits , University of Amsterdam, Netherlands (WG2)

Who attends?

Proteostasis brings together young researchers, established
investigators, leaders in their fields and industry representatives from
all around the world who work in the area of protein homeostasis. The
topics cover proteasome, autophagy, proteolysis, protein quality control
and mitochondrial proteostasis. A special effort in providing a total
of three session linking proteostasis research with health and diseases
ensures relevant content for health professionals as well. We aim at
providing a stimulating environment fostering both exchange and
generation of new ideas.

Undergraduate students
Master students
PhD students
Post-Docs
Researchers
Industry representatives

Abstracts will be selected for short talks (10 minutes presentation + 5 minutes Q&A)

BIOGRAPHIES

Biographies of the invited speakers

PROGRAM

November 2nd , 2016

14.00 – 16.00 COST PROTEOSTASIS MC MEETING
16.00 – 17.00 COST PROTEOSTASIS Working Groups MEETING
17.00 - 18.00 COST PROTEOSTASIS Translational Projects MEETING

November 3rd , 2016

08.00 - 08.30 Registration
08.30 - 08.45 Welcome Words

08.45 – 09.15 Keynotes of Day1 by Shigeo Murata, Tokyo University, Japan

09.15 –11.00 Session I: Intracellular proteolytic systems I: Proteasome structure, assembly and function (WG2)

Chairs: Arkaitz Carracedo Perez (WG6), Pascale Bomont (WG2)

09.15 - 09.40 Arkaitz Carracedo, CIC bioGUNE & IKERBASQUE, Spain
09.45 - 10.10 Prasanna Venkatraman, ACTREC, India
10.15 - 10.30 Shun Koizumi, Identification of the mechanism for Nrf1 activation in response to proteasome inhibition
10.30 - 10.45 Sabine Schipper-Krom, Alterations in Proteasome Complexes during Huntington’s Disease progression
10.45 - 11.00 Derek Wilkinson, Alternative proteasome expression in yeast: an in-silico analysis of transcription factor binding sites in proteasome subunits and assembly chaperones

11.00 - 11.30 Coffee break

11.30 - 13.15 Session II: Intracellular proteolytic systems II: Autophagy (WG2)
Chairs: Teresa Zoladek (WG2)

11.30 - 11.55 Anne Simonsen, University of Oslo, Norway (WG2)
12.00 - 12.25 Gabor Banhegyi, Semmelweis University , Hungary (WG4)
12.30 - 12.45 oão Vasco Ferreira, STUB1-Ataxin3 editing machine for the degradation of HIF1A by Chaperone-Mediated Autophagy
12.45 - 13.00 Steve Catarino, Interaction between Cx43 and LC3: an ubiquitin-independent pathway for degradation of Cx43 by autophagy
13.00 - 13.15 Charlotte Montespan, Adenoviruses limit membrane damage induced autophagy during cell entry through a conserved PPxY motif in capsid protein VI

13.15 - 14.30 Lunch and poster setup

14.30 - 16.45 Session III: Protein modification in intracellular proteolysis (WG1)

Chairs: Marc Piechaczyk (WG6), Isabelle Jupin (WG1), Sebastian Leon (WG1)

14.30 - 14.55 Frauke Melchior, ZMBH, Germany (WG3)
15.00 - 15.25 Amir Orian, Rappaport Research Institute, Israel (WG5)
15.30 - 15.45 Xènia Crespo –Yàñez, ESCRT-III CHMP1B activation and oligomerization are regulated by ubiquitination
15.45 - 16.00 Andreas Bachmair, SUMO chain formation links SUMO conjugation to ubiquitin-dependent protein degradation
16.00 - 16.25 Alfred Vertegaal , LUMC, Netherlands (WG1)
16.30 - 16.45 Sébastien Léon, A Set of Arrestin-Related Proteins Convey Glucose Signaling to Transporter Endocytosis
16.45 - 17.15 Coffee break

17.15 - 20.00 “Speed Poster” Presentations

November 4th, 2016

08.30 – 09.00 Keynotes of Day2 by Rosa Barrio, CIC bioGUNE, SPAIN (WG3)

09.00 - 10.15 Session IV: Protein quality control, misfolding and aggregation (WG4)
Chairs: Adrienne Gorman (WG4), Rasmus Hartmann-Petersen (WG4)
09.00 - 09.25 John Christianson, Ludwig Cancer Research, UK (WG4)
09.30 - 09.45 Quentin Defenouillère, The RQC complex remains bound to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregation
09.45 - 10.00 Liang Li, A conserved pro-survival function of the plant metacaspase AtMC1 during protein aggregate clearance
10.00 - 10.15 Sara Canato, CFTR traffic protein network in CF to modulate F508del-CFTR rescued

10.15 - 10.45 Coffee break

10.45 - 11.45 Session V: Mitochondria and proteostasis
Chair: Andreas Bachmair (WG1), Gemma Marfany (WG6)
10.45 - 11.10 Miratul Muqit, University of Dundee, UK
11.15 - 11.30 Thomas Meul, Mitochondrial dysfunction affects activity and composition of proteasome complexes
11.30 - 11.45 Vasileios Toulis, The involvement of deubiquitinating enzyme Ataxin-3 in retinal development

12.00 -13.30 Lunch

13.30 - 16.15 Session VI: Regulation of cell signaling I- Activation of signaling cascades (WG3)
Chairs: Dan Lindholm (WG3), Henrique Girao (WG3)
13.30 - 13.55 Michael Clague, University of Liverpool, UK (WG3)
14.00 - 14.25 Simona Polo, IFOM, Italy (WG3)
14.30 - 14.45 Rebecca L Eccles, ARHGAP36 mediates endolysosomal degradation of Protein Kinase A
14.45 - 15.00 Marco Trujillo, MAP-kinase controls functions of the exocyst subunit Exo70 in distinct processes
15.00 - 15.25 Fumiyo Ikeda, IMBA, Austria (WG2)

15.30 – 15.45 Miguel Cavadas, Beyond the ER: iRhom2-phosphorylation controls TACE activity at the cell surface

15.45 - 16.15 Coffee Break

16.15 – 17.45 Session VII: Tool Development in Proteostasis (WG6)
Chairs: Rune Matthiesen (WG1), Boris Turk (WG6)
16.15 – 16.40 Huib Ovaa, NKI Amsterdam, Netherlands (WG2)
16.45 - 17.10 Michael Glickman, Technion Israel Institute of Technology, Israel (WG1)
17.15 – 17.30 Rasmus Hartmann-Petersen, Thermodynamic instability of Lynch syndrome-causing MSH2 variants correlates with protein turnover
17.30 – 17.45 Manuel S. Rodriguez, Characterization of ubiquitylation defects associated with resistance to Adriamycin

18.00 – 19.00 “Speed Poster” Presentations

20.00 – 23.00 Dinner

November 5th, 2016

08.30 – 09.00 Keynotes of Day3 by Tilman Grune, German Institute of Human Nutrition, Germany

09.00 – 10.00 Session VIII: Regulation of cell proliferation and differentiation (WG5)
Chairs: Dimitris Xirodimas (WG5), Christine Blattner (WG5)
09.00 – 09.25 Dimitris Xirodimas
09.30 – 09.45 Rosa Farràs, Regulation of epithelial-mesenchymal transition mediated by translation factor eIF5a
09.45 – 10.00 Izabela Sumara, Targeting ubiquitin receptor protein UBASH3B for future cancer therapies

10.00 – 11.30 Session IX: Intracellular Proteostasis and Health I: Aging and Proteostasis WG6)
Chairs: Wiep Scheper (WG4), Efthimios Skoulakis (WG6)
10.00 - 10.25 Thorsten Hoppe, University of Cologne, Germany (WG4)
10.30 - 10.55 Carina Holmberg, University of Helsinki, Finland (WG2)

11.00 – 11.30 Coffee break

11.30 - 11.45 Belém Sampaio-Marques, The impact of α-synuclein on proteostasis and longevity: the crosstalk betwwenTor1 and Sir2
11.45 – 12.00 Pierre Goloubinoff, Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span

12.00 – 13.30 Lunch

13.30 – 15.00 Session X: Intracellular Proteostasis and Health II: Oxidative Stress and Proteostasis (WG6)
Chairs: Gerasimos Sykiotis (WG6)
13.30 – 13.55 Bertrand Friguet, INSERM, France
14.00 – 14.25 Niki Chondrogianni, NHRF, Greece (WG2)
14.30 - 14.45 Gerasimos P. Sykiotis, The genomic response of the mouse thyroid gland to iodine challenge and the role of the Nrf2 antioxidant system
14.45 - 15.00 Abhishek Sinha, Control of ergosterol synthesis: a new role of the CSN beyond CRLs regulation

15.00 - 15.30 Coffee break

15.30 – 17.45 Session XI: Intracellular Proteostasis and Health III: Human Diseases and Proteostasis (WG6)
Chairs: Rosa Farras Rivera (WG6)
15.30 – 15.55 Konstanze F. Winklhofer, Ruhr University Bochum, Germany
16.00 – 16.25 Eric Reits , University of Amsterdam, Netherlands (WG2)
16.30 – 16.45 Marc Piechaczyk,The ROS/SUMO axis in chemosensitivity versus chemoresistance of acute myeloid leukemia and as a potential novel therapeutic target
16.45 – 17.00 Philippe Soubeyran, Role of post-translational modifications by ubiquitin family of proteins in resistance mechanisms of pancreatic cancer cells
17.00 – 17.25 Gloria López-Castejón, Danger signals regulate USP7 activity to mediate inflammasome activation.
17.30 – 17.45 Ilona E. Kammerl, Deficiency of immunoproteasome subunit LMP2 increases alternative polarization of alveolar macrophages

17.45 – 18.00 Concluding and farewell remarks

REGISTRATION

All participants who wish to take part in the meeting MUST register and pay the fees according to the procedure indicated below.

For details on payment please download this Word form.docx, subsequently fill and send information to "proteostasis2016@gmail.com" together with proof of payment.

Registration Fees:

EARLY BIRD REGISTRATION (until the end of August 2016):

250€ Non- academic/industrial representatives
200€ PIs
150€ postdocs
100€ PhD students and other students

LATER REGISTRATION (until the 30th of September):
300€ Non- academic/industrial representatives
250€ PIs/post docs
250€ Students

Registrations are limited and it will be on a first-come first-served basis. Your place can only be confirmed after payment of the registration fee.

What is included with registration?

- Admission to plenary and session speaker talks
- Poster awards
- Conference materials
- Lunch service, conference dinner and coffee breaks