2019

Mendes C, Serpa J. Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung Cancer. Antioxidants (Basel). 2019 Nov 29;8(12):603. doi: 10.3390/antiox8120603.

Haider HF, Ribeiro SF, Martins C, Ribeiro D, Trigueiros N, Szczepek AJ, Caria H, Hoare DJ, Paço J, Borrego LM. Tinnitus, hearing loss and inflammatory processes in an older Portuguese population. Int J Audiol. 2019 Dec 12:1-10. doi: 10.1080/14992027.2019.1698775. Epub ahead of print. PMID: 31829778.

Patricio P, Paiva JA, Borrego LM. Immune Response in Bacterial and Candida Sepsis. Eur J Microbiol Immunol (Bp). 2019 Oct 4;9(4):105-113. doi: 10.1556/1886.2019.00011. PMID: 31934361; PMCID: PMC6945997.

Blanco E, Pérez-Andrés M, Arriba-Méndez S, Serrano C, Criado I, Del Pino-Molina L, Silva S, Madruga I, Bakardjieva M, Martins C, Serra-Caetano A, Romero A, Contreras-Sanfeliciano T, Bonroy C, Sala F, Martín A, Bastida JM, Lorente F, Prieto C, Dávila I, Marcos M, Kalina T, Vlkova M, Chovancova Z, Cordeiro AI, Philippé J, Haerynck F, López-Granados E, Sousa AE, van der Burg M, van Dongen JJM, Orfao A; EuroFlow PID group. Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies. J Allergy Clin Immunol. 2019 Sep;144(3):809-824. doi: 10.1016/j.jaci.2019.02.017. Epub 2019 Feb 28. PMID: 30826363.

Neves JF, Martins C, Cordeiro AI, Neves C, Plagnol V, Curtis J, Fabre M, Bibi S, Borrego LM, Moshous D, Nejentsev S, Gilmour K. Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation. J Pediatr Hematol Oncol. 2019 May;41(4):328-333. doi: 10.1097/MPH.0000000000001232. PMID: 29939941.

Pereira MA, Alexandre-Pires G, Câmara M, Santos M, Martins C, Rodrigues A, Adriana J, Passero LFD, Pereira da Fonseca I, Santos-Gomes G. Canine neutrophils cooperate with macrophages in the early stages of Leishmania infantum in vitro infection. Parasite Immunol. 2019 Apr;41(4):e12617. doi: 10.1111/pim.12617. Epub 2019 Mar 12. PMID: 30735568.

Sabino R, Veríssimo C, Viegas C, Viegas S, Brandão J, Alves-Correia M, Borrego LM, Clemons KV, Stevens DA, Richardson M. The role of occupational Aspergillus exposure in the development of diseases. Med Mycol. 2019 Apr 1;57(Supplement_2):S196-S205. doi: 10.1093/mmy/myy090. PMID: 30816970.

Lima J, Cambridge G, Vilas-Boas A, Martins C, Borrego LM, Leandro M. Serum markers of B-cell activation in pregnancy during late gestation, delivery, and the postpartum period. Am J Reprod Immunol. 2019 Mar;81(3):e13090. doi: 10.1111/aji.13090. Epub 2019 Jan 30. PMID: 30624814; PMCID: PMC6590212.

Alves-Correia M, Gaspar Â, Borrego LM, Azevedo J, Martins C, Morais-Almeida M. Successful oral desensitization in children with cow's milk anaphylaxis: Clinical and laboratory evaluation up to nine-years follow-up. Allergol Immunopathol (Madr). 2019 Mar-Apr;47(2):133-140. doi: 10.1016/j.aller.2018.07.007. Epub 2018 Oct 25. PMID: 30482599.

Marinho AT, Lu H, Pereira SA, Monteiro E, Gabra H, Recchi C. Anti-tumorigenic and Platinum-Sensitizing Effects of Apolipoprotein A1 and Apolipoprotein A1 Mimetic Peptides in Ovarian Cancer. Front. Pharmacol., 28 January 2019 | https://doi.org/10.3389/fphar.2018.01524

Gonçalves-Dias C, Morello J, Correia MJ, Coelho NR, Antunes AMM, Macedo MP, Monteiro EC, Soto K, Pereira SA. Mercapturate pathway in the tubulocentric perspective of diabetic kidney disease. Nephron 2019;143:17–23 https://doi.org/10.1159/000494390

Santos I, Ramos C, Mendes C, Sequeira CO, Tomé CS, Fernandes DGH, Mota P, Pires RF, Urso D, Hipólito A, Antunes AMM, Vicente JB, Pereira SA, Bonifácio VDB, Nunes SC, Serpa. Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation. Nutrients 2019, 11(10), 2523; https://doi.org/10.3390/nu11102523

Santos I, Ramos C, Mendes C, Sequeira CO, Tomé CS, Fernandes DGH, Mota P, Pires RF, Urso D, Hipólito A, Antunes AMM, Vicente JB, Pereira SA, Bonifácio VDB, Nunes SC, Serpa. Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation. Nutrients 2019, 11(10), 2523; https://doi.org/10.3390/nu11102523

Pereira SA, Antunes AMM. Special Issue “Adductomics: Elucidating the Environmental Causes of Disease”. High-Throughput 2019, 8(3), 17; https://doi.org/10.3390/ht8030017

Nunes J, Charneira C, Morello J, Rodrigues J, Pereira SA, Antunes AMM. Mass Spectrometry-Based Methodologies for Targeted and Untargeted Identification of Protein Covalent Adducts (Adductomics): Current Status and Challenges. High-Throughput 2019, 8(2), 9; https://doi.org/10.3390/ht8020009

Gonçalves-Dias C, Morello J, Semedo V, Correia MJ, Coelho NR, Monteiro EC, Antunes AMM, Pereira SA. The mercapturomic profile of health and non-communicable diseases. High-Throughput 2019, 8(2), 10; https://doi.org/10.3390/ht8020010

Marinho AT, Miranda JP, Caixas U, Charneira C, Gonçalves-Dias C, Marques MM, Monteiro EC, Antunes AMM, Pereira SA. Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity. Drug Metab Rev. 2019 Feb;51(1):76-90. https://doi.org/10.1080/03602532.2019.1577891

Lopes-Coelho F, Silva F, Gouveia-Fernandes S, Martins C, Lopes N, Domingues G, Brito C, Almeida AM, Pereira SA, Serpa J. Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis. Cells 2020, 9(1), 107; https://doi.org/10.3390/cells9010107

Rama K, Canhão H, Carvalho AM, Vinga S. AliClu - Temporal sequence alignment for clustering longitudinal clinical data. BMC Med Inform Decis Mak. 2019 Dec 30;19(1):289. doi: 10.1186/s12911-019-1013-7.

Rodrigues J, Rodrigues AM, Dias SS, Sousa RD, Branco JC, Canhão H (2019) Psoriatic arthritis and Ankylosing Spondylitis Impact on Health-related Quality of Life and Working Life: A Comparative Population-Based Study. Acta Reumatol Port. 2019 Dec 27 [Epub ahead of print].

Laires PA, Serrano-Alarcón M, Canhão H, Perelman J. Multimorbidity and intention to retire: a cross-sectional study on 14 European countries. Int J Public Health. 2019 Dec 20. doi: 10.1007/s00038-019-01322-0. [Epub ahead of print].

Maia I, Monjardino T, Frias B, Canhão H, Cunha Branco J, Lucas R, Santos AC. Food Insecurity in Portugal Among Middle- and Older-Aged Adults at a Time of Economic Crisis Recovery: Prevalence and Determinants. Food Nutr Bull. 2019 Dec;40(4):504-513. doi:10.1177/0379572119858170.

Canet LM, Sánchez-Maldonado JM, Cáliz R, Rodríguez-Ramos A, Lupiañez CB, Canhão H, Martínez-Bueno M, Escudero A, Segura-Catena J, Sorensen SB, Hetland ML, Soto-Pino MJ, Ferrer MA, García A, Glintborg B, Filipescu I, Pérez-Pampin E, González-Utrilla A, Nevot MÁL, Conesa-Zamora P, den Broeder A, De Vita S, Jacobsen SEH, Collantes-Estevez E, Quartuccio L, Canzian F, Fonseca JE, Coenen MJH, Andersen V, Sainz J. Correction: Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients. Pharmacogenomics J. 2019 Dec;19(6):582. doi: 10.1038/s41397-019-0084-2.

Melo A, Matias MA, Dias SS, Gregório MJ, Rodrigues AM, de Sousa RD, Canhão H, Perelman J. Is food insecurity related to health-care use, access and absenteeism? Public Health Nutr. 2019 Dec;22(17):3211-3219. doi: 10.1017/S1368980019001885. Epub 2019 Aug 6.

Marques AJ, Rodrigues A, Dias S, Canhão H, Branco J, Vaz C. Fall determinants in the adult Portuguese: do chronic conditions change the risk of falling? Acta Reumatol Port. 2019 Nov 19. [Epub ahead of print]

Caeiro C, Canhão H, Paiva S, Gomes LA, Fernandes R, Rodrigues AM, Sousa R, Pimentel-Santos F, Branco J, Fryxell AC, Vicente L, Cruz EB. Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation. PLoS One. 2019 Nov 15;14(11):e0225336. doi:10.1371/journal.pone.0225336. eCollection 2019.

Mendonça N, Kingston A, Granic A, Jagger C. Protein intake and transitions between frailty states and to death in very old adults: The Newcastle 85+ Study. Age & Ageing. 2019 Nov 11; 49(1)32. doi:10.1093/ageing/afz142.

Rodrigues AM and Canhão H (2019) Innovation and digital transformation to support clinical care and prevent osteoporosis related fractures. Acta Reumatol Port. 44 (3), 171-172. 2019 Nov 1.

Laires P, Nunes C, Rodrigues A, Canhão H, Branco JC. PMS41 Projection of the prevalence of rheumatic diseases in Portugal through the first half of the 21st century. Value in Health. 2019 Nov 1; 22(3); S701. doi:10.1016/j.jval.2019.09.1585.

Sánchez-Maldonado JM, Cáliz R, Canet L, Horst RT, Bakker O, den Broeder AA, Martínez-Bueno M, Canhão H, Rodríguez-Ramos A, Lupiañez CB, Soto-Pino MJ, García A, Pérez-Pampin E, González-Utrilla A, Escudero A, Segura-Catena J, Netea-Maier RT, Ferrer MÁ, Collantes-Estevez E, López Nevot MÁ, Li Y, Jurado M, Fonseca JE, Netea MG, Coenen MJH, Sainz J. Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium. Sci Rep. 2019 Oct 15;9(1):14812. doi: 10.1038/s41598-019-51255-0.

Sanmarti R, Veale DJ, Martin-Mola E, Escudero-Contreras A, González C, Ercole L, Alonso R, Fonseca JE; ToSpace Study Group. Reducing or Maintaining the Dose of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis in Clinical Remission: A Randomized, Open-Label Trial. Arthritis Rheumatol. 2019 Oct;71(10):1616-1625.

Sanmarti R, Veale DJ, Martin-Mola E, Escudero-Contreras A, González C, Ercole L, Alonso R, Fonseca JE; ToSpace Study Group. Reducing or Maintaining the Dose of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis in Clinical Remission: A Randomized, Open-Label Trial. Arthritis Rheumatol. 2019 Oct;71(10):1616-1625.

Caeiro C, Paiva S, Gomes L, Fernandes R, Canhão H, Rodrigues AM, Sousa R, Fryxell AC, Vicente L, Branco J, Cruz EB. AB1199 Barriers and facilitators to the implementation of a stratified model of care for low back pain patients in primary care in Portugal. Ann Rheum Dis. 2019 May 27;78:2060-2061. doi: 10.1136/annrheumdis-2019-eular.5930. Abstract only.

Caeiro C, Paiva S, Gomes L, Fernandes R, Canhão H, Rodrigues AM, Sousa R, Fryxell AC, Vicente L, Branco J, Cruz EB. AB1199 Barriers and facilitators to the implementation of a stratified model of care for low back pain patients in primary care in Portugal. Ann Rheum Dis. 2019 May 27;78:2060-2061. doi: 10.1136/annrheumdis-2019-eular.5930. Abstract only.

Neto A, Mourão AF, Oliveira-Ramos F, Gomes JM, Santos MJ, Campanilho-Marques R, Piotto D, Silva CA, Estanqueiro P, Fonseca JE, Tererri MT, Canhão H. SAT0509 Body mass index and disease activity in Portuguese and Brazilian juvenile idiopathic arthritis patients: results from Rheumatic Diseases Portuguese Register – Reuma.pt. Ann Rheum Dis. 2019 May 27;78:1344. doi: 10.1136/annrheumdis-2019-eular.6349. Abstract only.

Cruz EB, Gomes L, Branco J, Rodrigues AM, Fernandes R, Caeiro C, Paiva S, Pinto I, Moniz R, Canhão H. AB1254 Low-back pain chronicity in a primary care setting is associated with maladaptive psychosocial factors, other chronic pain condition and high levels of pain at baseline. Ann Rheum Dis 2019 May 27;78:2088. doi: 10.1136/annrheumdis-2019-eular.7670. Abstract only.

Spiliopoulou A, Colombo M, Plant D, Nair N, Cui J, Coenen MJ, Ikari K, Yamanaka H, Saevarsdottir S, Padyukov L, Bridges SL Jr, Kimberly RP, Okada Y, van Riel PLC, Wolbink G, van der Horst-Bruinsma IE, de Vries N, Tak PP, Ohmura K, Canhão H, Guchelaar HJ, Huizinga TW, Criswell LA, Raychaudhuri S, Weinblatt ME, Wilson AG, Mariette X, Isaacs JD, Morgan AW, Pitzalis C, Barton A, McKeigue P. Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40and CD39. Ann Rheum Dis. 2019 Aug;78(8):1055-1061. doi: 10.1136/annrheumdis-2018-214877. Epub 2019 Apr 29.

Sepriano AR, Ramiro S, Araújo FC, Machado PM, Rodrigues AM, Gouveia N, Eusébio M, Canhão H, Branco J. Performance of referral strategies for spondyloarthritis: a population-based nationwide study. Rheumatology (Oxford). 2019 Jun 1;58(6):1086-1094. doi: 10.1093/rheumatology/key436.

Canhao H, Masuko K, Nakamura H. Editorial: Nutrition and Metabolism in Rheumatic Diseases. Front Med (Lausanne). 2019 May 8;6:101. doi: 10.3389/fmed.2019.00101. eCollection 2019. No abstract available.

Castelo-Branco L, Silva IP, Canhão H, Awada A. Promising Immuno-Oncology Treatments Beyond the 2018 Nobel Prize. Acta Med Port. 2019 Apr 30;32(4):251-257. doi: 10.20344/amp.12040. Epub 2019 Apr 30. No abstract available.

Torre C, Guerreiro J, Mendes Z, Miranda A, Bragança F, Cristino J, Canhão H, Branco JC. Low persistence with oral biphosphonate treatment in postmenopausal osteoporosis. Acta Reumatol Port. 2019 Apr-Jun;44(2):114-125.

Rodrigues AM, Eusébio M, Rodrigues AB, Caetano-Lopes J, Lopes IP, Lopes A, Mendes JM, Coelho PS, Fonseca JE, Branco JC, Canhão H. Low Serum Levels of DKK2 Predict Incident Low-Impact Fracture in Older Women. JBMR Plus. 2019 Mar 28;3(7):e10179. doi: 10.1002/jbm4.10179. eCollection 2019 Jul.

Oliveira P, Zejnilovic L, Azevedo S, Rodrigues AM, Canhão H. Peer Adoption and Development of Health Innovations by Patients: National Representative Study of 6204 Citizens. J Med Internet Res. 2019 Mar 26;21(3):e11726. doi: 10.2196/11726.

Canet LM, Sánchez-Maldonado JM, Cáliz R, Rodríguez-Ramos A, Lupiañez CB, Canhão H, Martínez-Bueno M, Escudero A, Segura-Catena J, Sorensen SB, Hetland ML, Soto-Pino MJ, Ferrer MA, García A, Glintborg B, Filipescu I, Pérez-Pampin E, González-Utrilla A, Nevot MÁL, Conesa-Zamora P, Broeder AD, De Vita S, Jacobsen SEH, Collantes-Estevez E, Quartuccio L, Canzian F, Fonseca JE, Coenen MJH, Andersen V, Sainz J. Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients. Pharmacogenomics J. 2019 Feb;19(1):83-96. doi: 10.1038/s41397-018-0057-x. Epub 2018 Oct 5. Erratum in: Pharmacogenomics J. 2019 Feb 14.

Vidal B, Cascão R, Finnilä MAJ, Lopes IP, da Glória VG, Saarakkala S, Zioupos P, Canhão H, Fonseca JE. Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model. Rheumatology (Oxford). 2019 Feb 1;58(2):371. doi: 10.1093/rheumatology/key377. No abstract available.

Furtado S, Rodrigues A, Dias S, Branco JC, Canhão H. Self-reported low-energy fractures and associated risk factors in people with diabetes: A national population-based study. Diabetes Res Clin Pract. 2019 Jan;147:93-101. doi: 10.1016/j.diabres.2018.11.015. Epub 2018 Nov 24.

Pereira E Silva R, Romão VC, Neves M, Garcia R, Oliveira S, Brites J, Ramos FO, Canhão H, Palma Dos Reis J, Pereira da Silva JA, Lopes T. Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome. Lupus. 2019 Jan;28(1):27-33. doi: 10.1177/0961203318811605. Epub 2018 Nov 12.

Chatzidionysiou K, Lukina G, Gabay C, Hetland ML, Hauge EM, Pavelka K, Nordström D, Canhão H, Tomsic M, Rotar Z, Lie E, Kvien TK, van Vollenhoven RF, Saevarsdottir S. Smoking and response to rituximab in rheumatoid arthritis: results from an international European collaboration. Scand J Rheumatol. 2019 Jan;48(1):17-23. doi: 10.1080/03009742.2018.1466363. Epub 2018 Sep 27.

Sebastião CS*, Neto Z, de Jesus, Mirandela M, Jandondo D, Couto-Fernandéz JC, Tanuri A, Morais J, Brito M (2019) Genetic diversity and drug resistance of HIV-1 among infected pregnant women diagnosed in Luanda, Angola. PlOs One 14(11):e0225251 *PhD student in the lab

Fassad MR, Patel MP, Shoemark A, Cullup T, Hayward J, Dixon M, Rogers AV, Ollosson S, Jackson C, Goggin P, Hirst RA, Rutman A, Thompson J, Jenkins L, Aurora P, Moya E, Chetcuti P, O'Callaghan C, Morris-Rosendahl DJ, Watson CM, Wilson R, Carr S, Walker W, Pitno A, Lopes S, Morsy H, Shoman W, Pereira L, Constant C, Loebinger MR, Chung EMK, Kenia P, Rumman N, Fasseeh N, Lucas JS, Hogg C, Mitchison HM. Clinical utility of NGS diagnosis and disease stratification in a multiethnic primary ciliarydyskinesia cohort. J Med Genet. 2019 Dec 25. pii: jmedgenet-2019-106501. doi: 10.1136/jmedgenet-2019-106501. [Epub ahead of print]

Shinn, C, Salgado, R, Silvério-Rodrigues, D.. Programa Nacional para a Promoção da Atividade Física: O caso de Portugal.Cien Saude Colet [periódico na internet] (2019/Set). [Citado em 20/12/2019].

Moreiras H, Pereira FJC, Neto MV, Bento-Lopes L, Festas TC, Seabra MC, Barral DC. The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes. Pigment Cell Melanoma Res. 2019 Oct 30. doi: 10.1111/pcmr.12840. [Epub ahead of print]

Brandão AS, Bensimon-Brito A, Lourenço R, Borbinha J, Soares AR, Jacinto A. Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration. Journal of Cell Science 2019 : jcs.231993 doi: 10.1242/jcs.231993

Mendes C, Lopes-Coelho F, Ramos C, Martins F, Santos I, Rodrigues A, Silva F, André S, Serpa J. Unraveling FATP1, regulated by ER- as a targeted breast cancer innovative therapy, Scientific reports 2019, Oct 1;9(1):14107. doi: 10.1038/s41598-019-50531-3.

Casalou C, Faustino A, Silva F, Ferreira IC, Vaqueirinho D, Ferreira A, Castanheira P, Barona T, Ramalho JS, Serpa J*, Félix A*, Barral DC. Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling, Cancers 2019, Sep 29;11(10). pii: E1461. doi: 10.3390/cancers11101461. *Equal contribution

Mota P, Pires RF, Serpa J, Bonifácio VDB. L-Buthionine Sulfoximine Detection and Quantification in Polyurea Dendrimer Nanoformulations. Molecules. 2019, Aug 27;24(17). pii: E3111. doi: 10.3390/molecules24173111

Nunes J, Charneira C, Nunes C, Gouveia-Fernandes S, Serpa J, Morello J, Antunes AMM. A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications. Frontiers in Chemistry. 2019 Jul 31;7:532. doi: 10.3389/fchem.2019.00532.

Lopes-Coelho F, Silva F, Hipólito A, Cardoso BA, Serpa J. Acetylation drives hepatocyte nuclear factor 1 stability by blocking proteasome-mediated degradation. Journal of Cellular Biochemistry. 2019 Jun;120(6):9337-9344 doi: 10.1002/jcb.28209

Sanmarti R, Veale DJ, Martin-Mola E, Escudero-Contreras A, González C, Ercole L, Alonso R, Fonseca JE; ToSpace Study Group. Reducing or Maintaining the Dose of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis in Clinical Remission: A Randomized, Open-Label Trial. Arthritis Rheumatol. 2019 Oct;71(10):1616-1625. doi: 10.1002/art.40905. Epub 2019 Sep 24.

Cracchiolo M, Sacramento JF , Mazzoni A, Panarese A , Carpaneto J,Conde SV,* Micera S*. Decoding neural metabolic markers from the carotid sinus nerve in a type 2 diabetes model, 2019. doi: 10.1109/TNSRE.2019.2942398 (in press). * Shared last autorship

Figueiredo-Pereira C, Menezes R, Ferreira S, N. Santos C and Vieira HLA. Carbon Monoxide Released by CORM-A1 Prevents Yeast Cell Death via Autophagy Stimulation. 2019 July 25. pii: foz051. doi: 10.1093/femsyr/foz051.

Osório DN, Viana-Soares R, Marto JP, Mendonça MD, Silva HP, Quaresma C, Viana-Baptista M, Gamboa H and Vieira HLA. Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment. 2019. doi: 10.1186/s12872-019-1181-5

Sacramento JF, Olea E, Ribeiro MJ, Prieto-Lloret J, Melo BF, Gonzalez C, Martins FO, Monteiro EC, Conde SV.Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing. J Physiol. 2019 Aug 19. doi: 10.1113/JP274179.

Heleno B, Rodrigues DS. Multimorbidity and the Challenge to Deliver Personalised and Meaningful Health Care. Port J Public Health, 1:3. Doi: 10.1159/000502270

Lapao L, Pisco L. A reforma da atenção primária à saúde em Portugal, 2005-2018: o futuro e os desafios da maturidade. Cad. Saúde Pública 2019; 35 Sup 2:e00042418. Doi: 10.1590/0102-311X00042418

Kuhns S, Seixas C, Pestana S, Tavares B, Nogueira R, Jacinto R, Ramalho JS, Simpson JC, Andersen JS, Echard A, Lopes SS, Barral DC, Blacque OE. Rab35 controls cilium length, function and membrane composition. EMBO Rep. 2019 Aug 21:e47625. doi: 10.15252/embr.201847625.

Burkhalter MD, Sridhar A, Sampaio P, Jacinto R, Burczyk MS, Donow C, Angenendt M; Competence Network for Congenital Heart Defects Investigators, Hempel M5, Walther P, Pennekamp P, Omran H, Lopes SS, Ware SM, Philipp M. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. J Clin Invest. 2019 May 16;130:2841-2855. doi: 10.1172/JCI98890.

Lozza L, Moura-Alves P, Domaszewska T, Lage Crespo C5 Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Silviu Ungureanu B, Guhlich-Bornhof U, Koehler AB, Stäber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE. The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Sci Rep. 2019 Jul 26;9(1):10878. doi: 10.1038/s41598-019-47350-x.

Hayes MJ, Burgoyne T, Wavre-Shapton ST, Tolmachova T, Seabra MC, Futter CE. Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease. Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2515-2524. doi: 10.1167/iovs.19-26784.

Storck EM, Morales-Sanfrutos J, Serwa RA, Panyain N, Lanyon-Hogg T, Tolmachova T, Ventimiglia LN, Martin-Serrano J, Seabra MC, Wojciak-Stothard B, Tate EW. Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics. Nat Chem. 2019 Jun;11(6):552-561. doi: 10.1038/s41557-019-0237-6. Epub 2019 Apr 1.

Sanzà P, Evans RD, Briggs DA, Cantero M, Montoliu L, Patel S, Sviderskaya EV, Itzen A, Figueiredo AC, Seabra MC, Hume AN. Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a. J Cell Sci. 2019 Apr 30;132(9). pii: jcs212035. doi: 10.1242/jcs.212035.

Moreiras H, Lopes-da-Silva M, Seabra MC, Barral DC. Melanin processing by keratinocytes: A non-microbial type of host-pathogen interaction? Traffic. 2019 Apr;20(4):301-304. doi: 10.1111/tra.12638.

Rodrigues D, Dias CV, Heleno B. Como responder a dúvidas clínicas. Revista Portuguesa de Medicina Geral e Familiar, [S.l.], v. 35, n. 2, p. 155-66, maio 2019. ISSN 2182-5181.

Silvério Rodrigues D, Sousa PF, Basílio N, et al. Primary care physicians’ decision-making processes in the context of multimorbidity: protocol of a systematic review and thematic synthesis of qualitative research. BMJ Open 2019;9:e023832. doi: 10.1136/bmjopen-2018-023832

Ponte S, Jacinto A, Carvalho L. The occluding junction protein Neurexin-IV is required for tissue integrity in the Drosophila wing disc epithelium. Matters. Apr 5, 2019. DOI 10.19185/matters.201903000014

Viegas Dias C, Maria AR, Dias AC, Heleno B. Evidence‐based brunch to practise literature appraisal skills. Med Educ [Internet]. 2019 Mar 15

Hoffmann AC, Minakaki G, Menges S, Salvi R, Savitskiy S, Kazman A, Vicente Miranda H, Mielenz D, Klucken J, Winkler J, Xiang W. (2019) Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose. Sci Rep. 2019 Jan 24;9(1):544. doi: 10.1038/s41598-018-35811-8.

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